Favism: disordered erythrocyte calcium homeostasis

Favism: disordered erythrocyte calcium homeostasis.

The biochemical events that take place during acute hemolysis of G6PD-deficient subjects in favism are far from being elucidated. Evidence is here reported for a constantly and heavily disordered calcium homeostasis in the erythrocytes from seven favic patients. The abnormality, ie, a significantly impaired calcium ATPase activity and a parallel marked increase of intracellular calcium levels, ...

Abnormal erythrocyte calcium homeostasis in oxidant-induced hemolytic disease.

The processes leading to red cell destruction in oxidant-induced hemolytic disease are not yet fully known. Oxidant damage to hemoglobin per se may be insufficient to explain the process, and the involvement of membrane damage has been suggested. We now report that at least one crucial membrane function-exclusion of calcium-is disrupted by the potent oxidant phenylhydrazine. Phenylhydrazine, bo...

ANTICONVULSANT THERAPY-INDUCED ALTERATIONS IN CALCIUM HOMEOSTASIS

35 epileptic patients, aged 10 to 58 years (mean 23), who were taking anticonvulsant drugs were studied. The patients exhibited a 34% reduction in serum calcium levels, a 41 % increase in serum alkaline phosphatase activity and a slight but insignificant decrease in serum phosphate, compared to untreated controls. These changes appear to be related to the anticonvulsant drug taken, in the ...

Favism.

Modulation of calcium homeostasis and ATPase activity in erythrocyte membrane of patients afflicted with fluorosis

The present study was performed to evaluate effect of consumption of excessive fluoride in drinking water by individuals on erythrocyte membrane activity of Ca 2+ -ATPase and its transport mechanism of Ca 2+ ions. Areas with different fluoride concentration in drinking water were divided into five study groups viz; Control (0.63-1.00 mg/L), A-I (8.00-10.00 mg/L), A-II (10.01-12.00 mg/L), A-III ...